5 EASY FACTS ABOUT PKRRATING DESCRIBED

The activated enzyme then phosphorylates its big substrate, the translational initiation variable eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to the conserved family of four protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in response to unique stimuli12, triggering the integrated stress resp